mRNA structural dynamics shape Argonaute-target interactions
نویسندگان
چکیده
منابع مشابه
Structural features of Argonaute-GW182 protein interactions.
MicroRNAs (miRNAs) guide Argonaute (Ago) proteins to target mRNAs, leading to gene silencing. However, Ago proteins are not the actual mediators of gene silencing but interact with a member of the GW182 protein family (also known as GW proteins), which coordinates all downstream steps in gene silencing. GW proteins contain an N-terminal Ago-binding domain that is characterized by multiple GW re...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2020
ISSN: 1545-9993,1545-9985
DOI: 10.1038/s41594-020-0461-1